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PrintedAlignmentParser.feed() does not bound offset, and its length check cannot fire

Status: Open.

#5272 In biopython/biopython;

· dbolser opened on Aug 3, 2026

Incorrect reference handling in _arraycore initialization failure paths

Status: Open.

#5271 In biopython/biopython;

· stanbot8 opened on Aug 3, 2026

run_cealign segfaults on a zero fragment size, short coordinate entries, or tuples

Status: Open.

#5269 In biopython/biopython;

· dbolser opened on Jul 30, 2026

Proposition to add Radius of Gyration calculating function to Biopython

Status: Open.

#5257 In biopython/biopython;

· Grumb0t opened on Jul 7, 2026

Endian issue with binary CIF on ppc64 and sparc64 arch

Status: Open.

#5235 In biopython/biopython;

· schoekek opened on Jun 10, 2026

TLEN calculation when writing sam file

Enhancement

Status: Open.

Feature

#5232 In biopython/biopython;

· arzoopatel5 opened on Jun 3, 2026

PERF: SequentialSeqFileRandomAccess FASTA indexer does per-line regex on sequence lines

Status: Open.

#5197 In biopython/biopython;

· mmokrejs opened on Apr 17, 2026

Clarification on chain.id mapping in MMCIFParser: asym_id vs auth_asym_id

Status: Open.

#5195 In biopython/biopython;

· MaybeBio opened on Apr 15, 2026

Making Location objects hashable?

Enhancement

Status: Open.

Feature

#5193 In biopython/biopython;

· manulera opened on Apr 14, 2026

GenBank parsing - handle misplaced BASE COUNT line

Status: Open.

#5172 In biopython/biopython;

· manulera opened on Mar 3, 2026

C++ acceleration for mmCIF parsing (native "fast path" for coordinates)

Status: Open.

#5156 In biopython/biopython;

· Felixburton7 opened on Jan 27, 2026

Missing libm linkage causes undefined symbol errors

Status: Open.

#5137 In biopython/biopython;

· BwL1289 opened on Jan 9, 2026